Al Shifa Hospital, hit by missiles on Friday, is the largest in the 360-sq-km Gaza Strip.
In recent weeks Israel has said Hamas militants have hidden command centres and tunnels beneath it and other hospitals.
Hamas, health authorities and Shifa directors have denied that the group is concealing military infrastructure in or under the complex and have said they would welcome an international inspection.
WHAT IS SHIFA?
Shifa is a sprawling complex of buildings and courtyards a few hundred metres from Gaza City’s small fishing port, sandwiched between Beach refugee camp and the city’s Rimal neighbourhood.
Its name comes from the Arabic word "healing" - common for hospitals in the Middle East.
ITS HISTORY
It was built in 1946 during British rule, two years before Britain withdrew from Palestine. It survived the Egyptian invasion in 1948 and two decades of Egyptian military rule.
In 1967, Israel captured and occupied the Gaza Strip and Shifa remained a focal point - long before Hamas - where many Palestinians were taken during clashes with Israeli troops.
In 1971, the Times of London reported a gun battle between a Palestinian militant who hid under a bed in the nurses’ quarters and an Israeli army patrol that was searching the hospital.
In 1987, during the opening week of the First Intifada against Israeli occupation, The New York Times reported a confrontation when several hundred Palestinians outside Shifa threw rocks at Israeli soldiers while shouting, "Come and kill us all or get out!"
REDESIGN AND ENLARGEMENT
During the 1980s, the hospital complex was revamped and redesigned by Israeli architects, according to Israeli news reports.
Zvi Elhyani, founder of the Israel Architecture Archive, wrote on Ynet on Nov. 9: "With the aid of American support, Israel embarked on a project to revamp and enlarge the hospital complex. This undertaking also involved the installation of a subterranean concrete floor. In a grim twist, this underground area has been appropriated in recent years by Hamas," he wrote. without providing evidence of the claim.
CONTROL PASSES TO HAMAS
In 1994, Palestine Liberation Organization (PLO) leader Yasser Arafat’s Fatah-dominated security forces saluted the Palestinian flag when it was raised over the hospital when Palestinians were granted limited self-autonomy in Gaza during the Oslo peace process.
Effective control over it passed from the Fatah-dominated Palestinian Authority to Hamas after the Islamist group's surprise 2006 election victory, and 2007 military takeover of Gaza.
During the power struggle between Fatah and Hamas building up to that takeover, fighters from both sides were treated at Shifa and other hospitals, under a form of truce that neither would harm the other side’s wounded.
Israel has previously claimed that Hamas used underground areas in Shifa to hide - it said as much during a 2008-2009 war in which more than 1,400 Palestinians and 13 Israelis were killed. It was not possible to verify the claims.
