CHILLING PLATELETS CAN SAFELY EXPAND THEIR AVAILABILITY

Researchers who tested the use of refrigerated platelets say their ‌results could more than triple the supply available to help save bleeding patients.

Platelets are a blood component that’s crucial for clotting and stemming blood loss. Donated platelets are conventionally stored at room temperature with a five-to-seven-day shelf life.

At 27 hospitals in the U.S. and Australia, 1,000 children and adults undergoing cardiac surgery received either room-temperature platelets stored ​for less than seven days or chilled platelets.

Platelets refrigerated for up to three weeks were just as effective at treating bleeding as ​the room-temperature platelets, the researchers reported in JAMA.

A significant proportion of the 2.5 million room-temperature platelet units collected each ⁠year in the U.S. are wasted due to the short shelf life, the researchers noted.

The new findings “will dramatically improve the availability of platelets while ​also reducing waste, allowing hospitals that aren’t in major cities to afford to keep this life-saving blood product on hand for bleeding patients,” study leader ​Dr. Philip Spinella of the University of Pittsburgh said in a statement.

Presently, rural and community hospitals for the most part cannot justify keeping room-temperature platelets in stock because they don’t often treat severely bleeding patients, his team noted.

The researchers said their results are already under review by the U.S. Food and Drug Administration and by regulators ​in other countries.

OCCUPATIONAL RADIATION HITS U.S. AIRLINE CREWS HARDEST

In a large study of U.S. workers, flight attendants and pilots had the highest proportions of ​occupational radiation-related cancer deaths, researchers say.

Even nuclear medicine technologists, who are routinely exposed to radiation, had lower mortality rates from these cancers than flight and cabin crews, ‌the researchers ⁠reported in JAMA Internal Medicine.

They used the National Vital Statistics System to analyze death certificates collected between 2020 and 2024 from nearly 13 million decedents across 503 occupations, including roughly 14,000 pilots and 7,000 flight attendants.

They looked for deaths due to radiation-related cancers of the breast, central nervous system, blood, thyroid, prostate and skin.

After accounting for individual risk factors, the researchers found that pilots and flight attendants had statistically significantly higher rates of death from ​breast, central nervous system, and prostate ​cancers and melanoma.

Pilots also had ⁠a higher rate of leukemia deaths.

In all, about 6.9% of deaths among flight attendants and 6.7% of deaths among pilots were from radiation-related cancers, the researchers found.

Flight crew members were not at higher risk for non–radiation-related cancer ​deaths.

Pilots and flight attendants accrue an estimated 3 to 6 millisieverts per year of cosmic radiation, greatly ​exceeding the 0.4 millisieverts ⁠received by an air traveler taking 10 cross-country round-trip flights per year, according to the report.

While the U.S. Federal Aviation Administration formally recognizes these workers as occupationally exposed to ionizing radiation, they are not subject to federal dose limits or monitoring requirements — unlike other U.S. radiation-exposed workers or aircrew in other ⁠countries, the ​researchers noted.

The findings “…warrant attention from policymakers, regulators, airlines, and the clinicians who care for those ​who spend their working lives at altitude,” researchers not involved in the study wrote in an editorial.

In the meantime, the editorial advises, doctors should have “a heightened index of suspicion” when evaluating ​aircrew whose symptoms might be cancer-related.

( To receive the full newsletter in your inbox for free sign up here)