Novo's shares rose more than 5% to a fresh record-high on the news, trading 4.4% higher at 1312 GMT.
The Danish drugmaker said it now expects sales growth this year at between 32% and 38%, from a previous forecast of 27%-33%.
It raised its full-year outlook for growth in earnings before interest and tax (EBIT) to 40-46% from the previous 31-37% range.
Novo became Europe's most valuable company this year on soaring demand for weekly injection Wegovy and its lower-dose version Ozempic.
The new sales outlook for this year 2023 primarily reflects higher expectations for profits related to sales of Ozempic and Wegovy in the United States.
The Copenhagen-based company, which also raised its outlook in April and August, had initially forecast both sales and operating profit to grow by 13%-19% this year.
Sales grew 33% in the first nine months of the year and 38% in the third quarter, it said. Operating profit grew 37% between January and September, with 47% growth in the third quarter.
The company is due to disclose full quarterly numbers on Nov. 2.
